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X-WR-CALDESC:Events for Namur Institute For Complex Systems
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DTSTART;TZID=Europe/Paris:20170425T130000
DTEND;TZID=Europe/Paris:20170425T140000
DTSTAMP:20260409T084317
CREATED:20170308T152506Z
LAST-MODIFIED:20170331T155306Z
UID:147-1493125200-1493128800@www.naxys.be
SUMMARY:Francesco Piazza (University of Orléans)
DESCRIPTION:Title: Diffusion of small ligands in complex confining and reactive landscapes:\nthe geometry of chemoreception. \nAbstract: \nThe rate constant that describes the diffusive encounter/reaction between a particle\nand a large sphere can be computed easily by solving the stationary diffusion\n(i.e. Laplace) equation for the particle density with appropriate boundary conditions\nimposed on the surface of the sphere. In one classic\, text-book example\, this calculation is\nused to estimate the binding rate constant of a ligand to a receptor-covered cell.\nBut what happens if the particles are diffusing in the presence of many reactive boundaries\nof different strength (intrinsic reaction rate)\, which compete for the same ligands and amidst\na landscape of inert obstacles? In spite of the apparent overwhelming complexity\, the same mathematical framework as the two-body problem can be used to solve the N-body problem exactly\, by resorting to addition theorems for the appropriate fundamental solutions of the Laplace equation.\nThis powerful mathematical framework allows one to investigate fundamental issues\nthat are central in cell biology and modern nano-sciences\, such as how the specific geometric\nconfigurations of many reactive boundaries shape the overall reaction rate constant.\nWe will illustrate several examples\, including applications to the study of ligand binding\nto arrays of receptors on the surface of a cell and the action of many nano-catalysts embedded within a core-shell nano-reactor.
URL:https://www.naxys.be/event/francesco-piazza-university-of-orleans/
LOCATION:Seminar room\, Rempart de la Vierge 8\, Namur\, 1170
CATEGORIES:NAXYS Seminar
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